GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer

2016271 citationsJournal Articlehybrid Open Access

Authors

Paola Martinelli · Spanish National Cancer Research Centre

Enrique Carrillo de Santa Pau · Spanish National Cancer Research Centre

Trevor F. Cox · NIHR Liverpool Pancreatic Biomedical Research Unit

Bruno Sáinz · Universidad Autónoma de Madrid

Nelson Dusetti · Centre de Recherche en Cancérologie de Marseille

William Greenhalf · University of Liverpool

Lorenzo Rinaldi

Abstract

We provide mechanistic insight into GATA6 tumour-suppressive function, its role as a regulator of canonical epithelial differentiation, and propose that loss of GATA6 expression is both prognostic and predictive of response to adjuvant therapy.

Topics & Keywords

Pancreatic and Hepatic Oncology Research Epigenetics and DNA Methylation Cancer Genomics and Diagnostics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Gut

Volume 66, Issue 9, pp. 1665-1676

DOI: 10.1136/gutjnl-2015-311256

Field-Weighted Citation Impact: 8.20