Signal Transducer and Activator of Transcription 3/MicroRNA-21 Feedback Loop Contributes to Atrial Fibrillation by Promoting Atrial Fibrosis in a Rat Sterile Pericarditis Model

2016109 citationsJournal Articlegreen Open Access

Authors

Zhengrong Huang · Applied Pulsed Power (United States)

Xiaojun Chen · Applied Pulsed Power (United States)

Cheng Qian · Applied Pulsed Power (United States)

Qian Dong · Apple (Israel)

Dan Ding · Applied Pulsed Power (United States)

Qiongfeng Wu · TiGenix (Spain)

Jing Li ·

Abstract

Our results have uncovered a novel reciprocal loop between STAT3 and miR-21 that is activated after heart surgery and can contribute to atrial fibrillation.

Topics & Keywords

Cytokine Signaling Pathways and Interactions IL-33, ST2, and ILC Pathways Cardiac Fibrosis and Remodeling

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Arrhythmia and Electrophysiology

Volume 9, Issue 7

DOI: 10.1161/circep.115.003396

Field-Weighted Citation Impact: 5.52