Novel p38α MAP kinase inhibitors identified from yoctoReactor DNA-encoded small molecule library

201682 citationsJournal Articlehybrid Open Access

Authors

L. Petersen · Viper RF (United Kingdom)

Peter Blakskjær · Viper RF (United Kingdom)

A. Chaikuad · University of Oxford

Allan Beck Christensen · Viper RF (United Kingdom)

Judith Dietvorst · Viper RF (United Kingdom)

Johan Holmkvist · Viper RF (United Kingdom)

Stefan Knapp ·

Abstract

A DNA-encoded small-molecule library was prepared using yoctoReactor technology followed by binder trap enrichment to identify selective inhibitors with nanomolar potencies against p38α MAP kinase.

Topics & Keywords

Melanoma and MAPK Pathways Cancer Mechanisms and Therapy Protein Kinase Regulation and GTPase Signaling

Publication Details

Published in: MedChemComm

Volume 7, Issue 7, pp. 1332-1339

DOI: 10.1039/c6md00241b

Field-Weighted Citation Impact: 3.49

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Novel p38α MAP kinase inhibitors identified from yoctoReactor DNA-encoded small molecule library

Authors

Abstract

Topics & Keywords

Publication Details