Interleukin-6 induces impairment in human subcutaneous adipogenesis in obesity-associated insulin resistance

201694 citationsJournal Articlehybrid Open Access

Authors

Shamma Almuraikhy · Anti-Doping Laboratory

Wael Kafienah · University of Bristol

Moataz Bashah · Hamad Medical Corporation

Ilhame Diboun · Weill Cornell Medical College in Qatar

Morana Jaganjac · Anti-Doping Laboratory

Fatima Al‐Khelaifi · Anti-Doping Laboratory

Houari Abdesselem

Abstract

Obesity-associated insulin resistance is marked by impaired SC adipogenesis, mediated, at least in a subset of individuals, by elevated local levels of IL-6. Understanding the molecular mechanisms underlying reduced adipogenic capacity in IR individuals could help target appropriate therapeutic strategies aimed at those at greatest risk of insulin resistance and type 2 diabetes mellitus.

Topics & Keywords

Adipokines, Inflammation, and Metabolic Diseases Adipose Tissue and Metabolism Cardiovascular Disease and Adiposity

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Diabetologia

Volume 59, Issue 11, pp. 2406-2416

DOI: 10.1007/s00125-016-4031-3

Field-Weighted Citation Impact: 6.43