Increased global placental DNA methylation levels are associated with gestational diabetes

2016141 citationsJournal Articlegold Open Access

Authors

Christoph Reichetzeder · University of Potsdam

Sulistyo Emantoko Dwi Putra · University of Surabaya

Thiemo Pfab · Charité - Universitätsmedizin Berlin

Torsten Slowinski · Charité - Universitätsmedizin Berlin

Corinna Neuber · University of Potsdam

Burkhard Kleuser · University of Potsdam

Berthold Hocher

Abstract

This is the first study that employed a robust quantitative assessment of placental global DNA methylation in over a thousand placental samples. The study provides large scale evidence that placental global DNA hypermethylation is associated with GDM, independent of established risk factors.

Topics & Keywords

Epigenetics and DNA Methylation Gestational Diabetes Research and Management Congenital Diaphragmatic Hernia Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Epigenetics

Volume 8, Issue 1, pp. 82-82

DOI: 10.1186/s13148-016-0247-9

Field-Weighted Citation Impact: 8.35