Survival of Del17p CLL Depends on Genomic Complexity and Somatic Mutation

201693 citationsJournal Articlebronze Open Access

Authors

Lijian Yu · Dana-Farber Cancer Institute

Haesook T. Kim

Siddha Kasar · Harvard University

Parul Benien · Brigham and Women's Hospital

Wei Du · Brigham and Women's Hospital

Kevin Hoang · Dana-Farber Cancer Institute

Andrew Aw

Bethany Tesar ·

Abstract

We conclude that del(17p) has a unique genomic profile and that clonal TP53 mutations, 3p, 4p, or 9p deletions, and genomic complexity are associated with shorter overall survival. Clin Cancer Res; 23(3); 735-45. ©2016 AACR.

Topics & Keywords

Chronic Lymphocytic Leukemia Research Immunodeficiency and Autoimmune Disorders Lymphoma Diagnosis and Treatment

UN Sustainable Development Goals

No poverty

Publication Details

Published in: Clinical Cancer Research

Volume 23, Issue 3, pp. 735-745

DOI: 10.1158/1078-0432.ccr-16-0594

Field-Weighted Citation Impact: 7.66