Comprehensive analyses of tumor immunity: implications for cancer immunotherapy

20162,744 citationsJournal Articlegold Open Access

Authors

Bo Li · Harvard University

Eric A. Severson · Dana-Farber Cancer Institute

Jean‐Christophe Pignon · Brigham and Women's Hospital

Haoquan Zhao · Dana-Farber Cancer Institute

Taiwen Li · Sichuan University

Jesse Novak · Harvard University

Peng Jiang ·

Abstract

We develop a computational approach to study tumor-infiltrating immune cells and their interactions with cancer cells. Our resource of immune-infiltrate levels, clinical associations, as well as predicted therapeutic markers may inform effective cancer vaccine and checkpoint blockade therapies.

Topics & Keywords

Cancer Immunotherapy and Biomarkers Immunotherapy and Immune Responses Immune cells in cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Genome biology

Volume 17, Issue 1, pp. 174-174

DOI: 10.1186/s13059-016-1028-7

Field-Weighted Citation Impact: 38.49