Silencing Prion Protein in HT29 Human Colorectal Cancer Cells Enhances Anticancer Response to Fucoidan

201631 citationsJournal Articlebronze Open Access

Authors

Chul Won Yun · Soonchunhyang University Hospital

Seungpil Yun

Jun Hee Lee

Yong‐Seok Han · Soonchunhyang University Hospital

Yeo Min Yoon · Soonchunhyang University Hospital

Daniel An

Sang Hun Lee · Soonchunhyang University Hospital

Abstract

Combination of fucoidan with silencing of PrP(c) has a synergic effect on the inhibition of HT29 colon cancer cell growth. Furthermore, we provide evidence for the therapeutic application of PrP(c) silencing with other anticancer drugs for cancer.

Topics & Keywords

Prion Diseases and Protein Misfolding Seaweed-derived Bioactive Compounds Folate and B Vitamins Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Anticancer Research

Volume 36, Issue 9, pp. 4449-4458

DOI: 10.21873/anticanres.10989

Field-Weighted Citation Impact: 1.02