Biocompatibility and Pharmacokinetic Analysis of an Intracameral Polycaprolactone Drug Delivery Implant for Glaucoma

201669 citationsJournal Articlegold Open Access

Authors

Jean Kim

Max Kudisch · University of California, San Francisco

Sri Mudumba · Santen (United States)

Hiroyuki Asada · Santen (Japan)

Eri Aya-Shibuya · Santen (Japan)

Robert B. Bhisitkul · University of California, San Francisco

Tejal A. Desai · University of California, San Francisco

Abstract

Proof-of-concept PCL drug delivery devices containing DE-117 show promise as a long-term glaucoma treatment based on their zero-order drug release profile in vitro, biocompatibility in vivo, and effective distribution of released drug in relevant ocular tissues.

Topics & Keywords

Glaucoma and retinal disorders Intraocular Surgery and Lenses Corneal Surgery and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Investigative Ophthalmology & Visual Science

Volume 57, Issue 10, pp. 4341-4341

DOI: 10.1167/iovs.16-19585

Field-Weighted Citation Impact: 5.78