Exploiting Noncovalent Interactions in an Imine‐Based Covalent Organic Framework for Quercetin Delivery

2016378 citationsJournal Article

Authors

Vijay S. Vyas · Max Planck Institute for Solid State Research

Medhavi Vishwakarma · Max Planck Institute for Intelligent Systems

Igor Moudrakovski · Max Planck Institute for Solid State Research

Frederik Haase · Ludwig-Maximilians-Universität München

Gökçen Savaşçı · Ludwig-Maximilians-Universität München

Christian Ochsenfeld · Ludwig-Maximilians-Universität München

Joachim P. Spatz

Abstract

Covalent organic frameworks (COFs) are a new class of nanoporous polymeric vector showing promise as drug-delivery vehicles with high loading capacity and biocompatibility. The interaction between the carrier and the cargo is specifically tailored on a molecular level by H-bonding. Cell-proliferation studies indicate higher efficacy of the drug in cancer cells by nanocarrier delivery mediated by the COF.

Topics & Keywords

Covalent Organic Framework Applications Metal-Organic Frameworks: Synthesis and Applications Luminescence and Fluorescent Materials

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Advanced Materials

Volume 28, Issue 39, pp. 8749-8754

DOI: 10.1002/adma.201603006

Field-Weighted Citation Impact: 18.87