Incidence and Risk Factors for Developing Dengue-Associated Hemophagocytic Lymphohistiocytosis in Puerto Rico, 2008 - 2013

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Authors

Esther M. Ellis · Centers for Disease Control and Prevention

Tyler M. Sharp · Puerto Rico Department of Health

Janice Pérez‐Padilla · Centers for Disease Control and Prevention

González Liza · Ponce Health Sciences University

B. Katherine Poole‐Smith · Puerto Rico Department of Health

Emmaculate Lebo · Centers for Disease Control and Prevention

Charlotte Baker

Abstract

During this cluster of dengue-associated HLH cases that was temporally associated with the 2012-2013 epidemic, most patients with dengue-associated HLH were infants and had higher morbidity than dengue inpatients. Physicians throughout the tropics should be aware of HLH as a potential complication of dengue, particularly in patients with anemia and severe liver injury.

Topics & Keywords

Autoimmune and Inflammatory Disorders Research Mosquito-borne diseases and control Viral Infections and Vectors

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS neglected tropical diseases

Volume 10, Issue 8, pp. e0004939-e0004939

DOI: 10.1371/journal.pntd.0004939

Field-Weighted Citation Impact: 3.64