Cancer Stem Cells in Glioblastoma Multiforme

201675 citationsJournal Articlegold Open Access

Authors

Amy Bradshaw · Gillies McIndoe Research Institute

Agadha Wickremesekera · Wellington Hospital

Helen D. Brasch · Gillies McIndoe Research Institute

Alice M. Chibnall · Gillies McIndoe Research Institute

Paul F. Davis · Gillies McIndoe Research Institute

Swee T. Tan · Hutt Hospital

Tinte Itinteang

Abstract

This study demonstrated a population of CSCs within GBM characterized by the expression of the CSC markers NANOG, SALL4, SOX2, pSTAT3 and OCT4 at the protein and mRNA levels. The almost ubiquitous presence of SOX2 and a relatively low abundance of OCT4 would support the putative existence of a stem cell hierarchy within GBM.

Topics & Keywords

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Frontiers in Surgery

Volume 3, pp. 48-48

DOI: 10.3389/fsurg.2016.00048

Field-Weighted Citation Impact: 5.40