Polymyxin monotherapy or in combination against carbapenem-resistant bacteria: systematic review and meta-analysis

2016166 citationsReviewbronze Open Access

Authors

Oren Zusman · Rabin Medical Center

Sergey Altunin · Technion – Israel Institute of Technology

Fidi Koppel · Rambam Health Care Campus

Yael Dishon Benattar · University of Haifa

Habip Gedık · Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi

Mical Paul · Rambam Health Care Campus

Abstract

The significant association observed in observational studies between polymyxin monotherapy and mortality cannot be taken as proof of combination therapy effects due to the low quality of the evidence. The only three RCTs to date show no effect of rifampicin/colistin or fosfomycin/colistin on mortality for Acinetobacter infections.

Topics & Keywords

Antibiotic Resistance in Bacteria Antibiotics Pharmacokinetics and Efficacy Pneumonia and Respiratory Infections

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Antimicrobial Chemotherapy

Volume 72, Issue 1, pp. 29-39

DOI: 10.1093/jac/dkw377

Field-Weighted Citation Impact: 8.25