Novel regional age-associated DNA methylation changes within human common disease-associated loci

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Authors

Christopher G. Bell · King's College London

Yudong Xia · BGI Group (China)

Wei Yuan · Institute of Cancer Research

Fei Gao · BGI Group (China)

Kirsten Ward · King's College London

Leonie Roos · King's College London

Massimo Mangino ·

Abstract

By analysing the functionally enriched disease and trait-associated regions of the human genome, we identify novel epigenetic ageing changes, which could be useful biomarkers or provide mechanistic insights into age-related common diseases.

Topics & Keywords

Epigenetics and DNA Methylation Cancer-related gene regulation RNA modifications and cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Genome biology

Volume 17, Issue 1, pp. 193-193

DOI: 10.1186/s13059-016-1051-8

Field-Weighted Citation Impact: 3.66