Association Between Low-Density Lipoprotein Cholesterol–Lowering Genetic Variants and Risk of Type 2 Diabetes

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Authors

Luca A. Lotta · University of Cambridge

Stephen J. Sharp · MRC Epidemiology Unit

Stephen Burgess · University of Cambridge

John R. B. Perry · MRC Epidemiology Unit

Isobel D. Stewart · University of Cambridge

Sara M. Willems · University of Cambridge

Jian’an Luan ·

Abstract

In this meta-analysis, exposure to LDL-C-lowering genetic variants in or near NPC1L1 and other genes was associated with a higher risk of type 2 diabetes. These data provide insights into potential adverse effects of LDL-C-lowering therapy.

Topics & Keywords

Genetic Associations and Epidemiology Cholesterol and Lipid Metabolism Lipoproteins and Cardiovascular Health

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA

Volume 316, Issue 13, pp. 1383-1383

DOI: 10.1001/jama.2016.14568

Field-Weighted Citation Impact: 50.43