Age as a Confounding Factor for the Accurate Non-Invasive Diagnosis of Advanced NAFLD Fibrosis

2016863 citationsJournal Articlegreen Open Access

Authors

Stuart McPherson · Newcastle University

Timothy Hardy · Newcastle University

Jean‐François Dufour · University of Bern

Salvatore Petta · University of Palermo

Manuel Romero‐Gómez · Hospital Universitario Virgen Macarena

Mike Allison · NIHR Cambridge Biomedical Research Centre

Cláudia P. Oliveira

Abstract

The NFS and FIB-4 scores have similar accuracy for advanced fibrosis in patients aged >35 years. However, the specificity for advanced fibrosis is unacceptably low in patients aged ≥65 years, resulting in a high false positive rate. New thresholds for use in patients aged ≥65 years are proposed to address this issue.

Topics & Keywords

Liver Disease Diagnosis and Treatment Liver Diseases and Immunity Liver Disease and Transplantation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The American Journal of Gastroenterology

Volume 112, Issue 5, pp. 740-751

DOI: 10.1038/ajg.2016.453

Field-Weighted Citation Impact: 23.14