Preclinical Study of Single-Dose Moxidectin, a New Oral Treatment for Scabies: Efficacy, Safety, and Pharmacokinetics Compared to Two-Dose Ivermectin in a Porcine Model

201696 citationsJournal Articlegold Open Access

Authors

Charlotte Bernigaud · École Nationale Vétérinaire d'Alfort

Fang Fang · Guangxi University

Katja Fischer · QIMR Berghofer Medical Research Institute

Anne Lespine · Université Toulouse III - Paul Sabatier

Serge Aho · Biology of Infection

Dominique Dreau

Andrew B. Kelly · The University of Queensland

Abstract

Our data demonstrate that oral single-dose MOX was more effective than two consecutive IVM-doses, supporting MOX as potential therapeutic approach for scabies.

Topics & Keywords

Dermatological diseases and infestations Complementary and Alternative Medicine Studies Nail Diseases and Treatments

UN Sustainable Development Goals

Responsible consumption and production

Publication Details

Published in: PLoS neglected tropical diseases

Volume 10, Issue 10, pp. e0005030-e0005030

DOI: 10.1371/journal.pntd.0005030

Field-Weighted Citation Impact: 6.69