FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders

2016216 citationsJournal Articlebronze Open Access

Authors

Jenni M. Lehtonen · MRC Mitochondrial Biology Unit

Saara Forsström · MRC Mitochondrial Biology Unit

Emanuela Bottani · MRC Mitochondrial Biology Unit

Carlo Viscomi · MRC Mitochondrial Biology Unit

Olivier R. Baris · MRC Mitochondrial Biology Unit

Helena Isoniemi · MRC Mitochondrial Biology Unit

Krister Höckerstedt

Abstract

This study provides Class III evidence that elevated S-FGF21 accurately distinguishes patients with mitochondrial myopathies from patients with other conditions, and FGF21 and GDF15 mitochondrial myopathy from other myopathies.

Topics & Keywords

Fibroblast Growth Factor Research RNA modifications and cancer Connective tissue disorders research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Neurology

Volume 87, Issue 22, pp. 2290-2299

DOI: 10.1212/wnl.0000000000003374

Field-Weighted Citation Impact: 9.75