MEFV and SAA1 genotype associations with clinical features of familial Mediterranean fever and amyloidosis in Armenia.

201721 citationsJournal Article

Authors

Stepan Atoyan · Center of Medical Genetics and Primary Health Care

Hasmik Hayrapetyan · Center of Medical Genetics and Primary Health Care

Tamara Sarkisian · Center of Medical Genetics and Primary Health Care

Eldad Ben‐Chetrit · Hadassah Medical Center

Abstract

The SAA1 α allele is strongly associated with amyloidosis in FMF patients. This observation is valid in inflammatory diseases other than FMF too. SAA1 polymorphism has no effect on the clinical features of FMF. M694V homozygosis is highly associated withal typical features of FMF and with amyloidosis. FMF course in Armenia is similar to that in Middle Eastern countries where FMF disease is common.

Topics & Keywords

Inflammasome and immune disorders interferon and immune responses Cholesterol and Lipid Metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PubMed

Volume 34, Issue 6 Suppl 102, pp. 72-76

Field-Weighted Citation Impact: 0.96