Irisin Lowers Blood Pressure by Improvement of Endothelial Dysfunction via AMPK‐Akt‐eNOS‐NO Pathway in the Spontaneously Hypertensive Rat

2016137 citationsJournal Articlegold Open Access

Authors

Jinjuan Fu · Army Medical University

Yu Han · Daping Hospital

Jialiang Wang · Army Medical University

Yukai Liu · Daping Hospital

Shuo Zheng · Daping Hospital

Lin Zhou · Army Medical University

Pedro A. José · George Washington University

Abstract

We conclude that acute administration of irisin lowers blood pressure of SHRs by amelioration of endothelial dysfunction of the mesenteric artery through the AMPK-Akt-eNOS-NO signaling pathway.

Topics & Keywords

Adipose Tissue and Metabolism Eicosanoids and Hypertension Pharmacology Metabolomics and Mass Spectrometry Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of the American Heart Association

Volume 5, Issue 11

DOI: 10.1161/jaha.116.003433

Field-Weighted Citation Impact: 6.62