A human brain network derived from coma-causing brainstem lesions

2016264 citationsJournal Article

Authors

David Fischer · Harvard University

Aaron D. Boes · Massachusetts General Hospital

Athéna Demertzi · Massachusetts General Hospital

HC Evrard · Massachusetts General Hospital

Steven Laureys · Harvard University

Brian L. Edlow · Massachusetts General Hospital

Hesheng Liu ·

Abstract

Injury to a small region in the pontine tegmentum is significantly associated with coma. This brainstem site is functionally connected to 2 cortical regions, the AI and pACC, which become disconnected in disorders of consciousness. This network of brain regions may have a role in the maintenance of human consciousness.

Topics & Keywords

Functional Brain Connectivity Studies Traumatic Brain Injury Research Traumatic Brain Injury and Neurovascular Disturbances

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Neurology

Volume 87, Issue 23, pp. 2427-2434

DOI: 10.1212/wnl.0000000000003404

Field-Weighted Citation Impact: 12.66