Benefits and Risks of Antiretroviral Therapy for Perinatal HIV Prevention

2016340 citationsJournal Articlebronze Open Access

Authors

Mary Glenn Fowler · National Institute of Child Health

Min Qin · National Institutes of Health

Susan A. Fiscus · Johns Hopkins University

Judith S. Currier · Johns Hopkins University

Patricia M. Flynn · Johns Hopkins University

Tsungai Chipato · National Institute of Child Health

James McIntyre

Abstract

Antenatal ART resulted in significantly lower rates of early HIV transmission than zidovudine alone but a higher risk of adverse maternal and neonatal outcomes. (Funded by the National Institutes of Health; PROMISE ClinicalTrials.gov numbers, NCT01061151 and NCT01253538 .).

Topics & Keywords

HIV/AIDS Research and Interventions HIV-related health complications and treatments HIV, Drug Use, Sexual Risk

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 375, Issue 18, pp. 1726-1737

DOI: 10.1056/nejmoa1511691

Field-Weighted Citation Impact: 25.87