Increased MicroRNA-1 and MicroRNA-133a Levels in Serum of Patients With Cardiovascular Disease Indicate Myocardial Damage

2011591 citationsJournal Articlebronze Open Access

Authors

Yasuhide Kuwabara · Kyoto University

Koh Ono · Kyoto University

Takahiro Horie · Kyoto University

Hitoo Nishi · Kyoto University

Kazuya Nagao · Kyoto University

Minako Kinoshita · Kyoto University

Shin Watanabe · Kyoto University

Abstract

These results suggest that elevated levels of circulating miR-133a in patients with cardiovascular diseases originate mainly from the injured myocardium. Circulating miR-133a can be used as a marker for cardiomyocyte death, and it may have functions in cardiovascular diseases.

Topics & Keywords

MicroRNA in disease regulation Circular RNAs in diseases Extracellular vesicles in disease

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Cardiovascular Genetics

Volume 4, Issue 4, pp. 446-454

DOI: 10.1161/circgenetics.110.958975

Field-Weighted Citation Impact: 15.96