A Non-Human Primate Model of Severe Pneumococcal Pneumonia

201636 citationsJournal Articlegold Open Access

Authors

Luis Felipe Reyes · The University of Texas Health Science Center at San Antonio

Marcos I. Restrepo · The University of Texas Health Science Center at San Antonio

Cecilia A. Hinojosa · South Texas Veterans Health Care System

Nilam J. Soni · The University of Texas Health Science Center at San Antonio

Anukul T. Shenoy · University of Alabama at Birmingham

Ryan P. Gilley · The University of Texas Health Science Center at San Antonio

Abstract

We have developed a novel animal model for severe pneumococcal pneumonia that mimics the clinical presentation, inflammatory response, and infection kinetics seen in humans. This is a novel model to test vaccines and treatments, measure biomarkers to diagnose pneumonia, and predict outcomes.

Topics & Keywords

Pneumonia and Respiratory Infections Ultrasound in Clinical Applications Pleural and Pulmonary Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 11, Issue 11, pp. e0166092-e0166092

DOI: 10.1371/journal.pone.0166092

Field-Weighted Citation Impact: 4.29