Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease

20161,443 citationsJournal Articlegreen Open Access

Authors

Amit V. Khera · Center for Human Genetics

Connor A. Emdin · Broad Institute

Isabel Drake · Lund University

Pradeep Natarajan · Center for Human Genetics

Alexander G. Bick · Broad Institute

Nancy R. Cook · Brigham and Women's Hospital

Daniel I. Chasman ·

Abstract

Across four studies involving 55,685 participants, genetic and lifestyle factors were independently associated with susceptibility to coronary artery disease. Among participants at high genetic risk, a favorable lifestyle was associated with a nearly 50% lower relative risk of coronary artery disease than was an unfavorable lifestyle. (Funded by the National Institutes of Health and others.).

Topics & Keywords

Cardiovascular Health and Risk Factors Birth, Development, and Health Genetic Associations and Epidemiology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 375, Issue 24, pp. 2349-2358

DOI: 10.1056/nejmoa1605086

Field-Weighted Citation Impact: 89.55