Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis

201668 citationsReviewdiamond Open Access

Authors

Pradeep Natarajan

Joshua C. Bis

Lawrence F. Bielak

Amanda J. Cox · Cox & Company (United States)

Marcus Dörr · Marcus (United States)

Mary F. Feitosa

Nora Franceschini · Northern Ohio Recovery Association

Xiuqing Guo · State Administration of Foreign Experts Affairs

Shih-Jen Hwang

Abstract

Exome-wide association meta-analysis demonstrates that protein-coding variants in APOB and APOE associate with subclinical atherosclerosis. APOE ε2 represents the first significant association for multiple subclinical atherosclerosis traits across multiple ethnicities, as well as clinical coronary heart disease.

Topics & Keywords

Genetic Associations and Epidemiology Cardiovascular Function and Risk Factors Atherosclerosis and Cardiovascular Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Cardiovascular Genetics

Volume 9, Issue 6, pp. 511-520

DOI: 10.1161/circgenetics.116.001572

Field-Weighted Citation Impact: 7.21