Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures

20161,028 citationsJournal Articlegold Open Access

Authors

Yasin Şenbabaoğlu · Swim Across America

Ron S. Gejman · Cornell University

Andrew Winer · Memorial Sloan Kettering Cancer Center

Ming Liu · Memorial Sloan Kettering Cancer Center

Eliezer M. Van Allen · Dana-Farber Cancer Institute

Guillermo de Velasco · Dana-Farber Cancer Institute

Diana Miao

Abstract

Our analysis sheds light on the immune infiltration patterns of 19 human cancers and unravels mRNA signatures with prognostic utility and immunotherapeutic biomarker potential in ccRCC.

Topics & Keywords

Cancer Immunotherapy and Biomarkers Ferroptosis and cancer prognosis Immune cells in cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Genome biology

Volume 17, Issue 1, pp. 231-231

DOI: 10.1186/s13059-016-1092-z

Field-Weighted Citation Impact: 20.96