Self-assembled Pt<sub>2</sub>L<sub>2</sub> boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells

201648 citationsJournal Articlehybrid Open Access

Authors

Olaya Domarco · Universidade da Coruña

Daniela Lötsch · Institute of Cancer Research

John R. Schreiber · Institute of Cancer Research

Carina Dinhof · Institute of Cancer Research

Sushilla van Schoonhoven · Institute of Cancer Research

Marcos D. García · Universidade da Coruña

Carlos Peinador

Abstract

Supramolecular Pt(ii) quadrangular boxes bind native and G-quadruplex DNA motifs in a size-dependent fashion. Three Pt molecular squares of distinct size show biological activity against cancer cells and heavily influence the expression of genes known to form G-quadruplexes in their promoter regions. The smallest Pt-box displays less activity but more selectivity for a quadruplex formed in the c-Kit gene.

Topics & Keywords

DNA and Nucleic Acid Chemistry Advanced biosensing and bioanalysis techniques RNA Interference and Gene Delivery

Publication Details

Published in: Dalton Transactions

Volume 46, Issue 2, pp. 329-332

DOI: 10.1039/c6dt03876j

Field-Weighted Citation Impact: 3.31

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Self-assembled Pt<sub>2</sub>L<sub>2</sub> boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells

Authors

Abstract

Topics & Keywords

Publication Details