Metformin Is Associated With Higher Relative Abundance of Mucin-Degrading <i>Akkermansia muciniphila</i> and Several Short-Chain Fatty Acid–Producing Microbiota in the Gut

2016690 citationsJournal Article

Authors

Jacobo de la Cuesta‐Zuluaga · Fundación Con Vida

Noel T. Mueller · Johns Hopkins University

Vanessa Corrales-Agudelo · Fundación Con Vida

Eliana P. Velásquez-Mejía · Fundación Con Vida

Jenny Andrea Carmona

José M. Abad

Juan S. Escobar · Fundación Con Vida

Abstract

Our results support the hypothesis that metformin shifts gut microbiota composition through the enrichment of mucin-degrading A. muciniphila as well as several SCFA-producing microbiota. Future studies are needed to determine if these shifts mediate metformin's glycemic and anti-inflammatory properties.

Topics & Keywords

Gut microbiota and health Helicobacter pylori-related gastroenterology studies Clostridium difficile and Clostridium perfringens research

Publication Details

Published in: Diabetes Care

Volume 40, Issue 1, pp. 54-62

DOI: 10.2337/dc16-1324

Field-Weighted Citation Impact: 24.59

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Metformin Is Associated With Higher Relative Abundance of Mucin-Degrading <i>Akkermansia muciniphila</i> and Several Short-Chain Fatty Acid–Producing Microbiota in the Gut

Authors

Abstract

Topics & Keywords

Publication Details