PI3K/Akt/mTOR Intracellular Pathway and Breast Cancer: Factors, Mechanism and Regulation

2017140 citationsReview

Authors

Varruchi Sharma · Maharishi Markandeshwar University, Mullana

Girish Kumar Gupta · Maharishi Markandeshwar University, Mullana

Anil Kumar Sharma · Maharishi Markandeshwar University, Mullana

Navneet Batra · Gurukul School of Design

Daljit K. Sharma · Gurukul School of Design

Amit Joshi

Abstract

Structure and regulation/deregulation of mTOR provides a greater insight into the action mechanism. Also, through this review, one could easily scan first and second generation inhibitors for PI3K/Akt/mTOR pathway besides targeted therapies for breast cancer and the precise role of mTOR.

Topics & Keywords

PI3K/AKT/mTOR signaling in cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Current Pharmaceutical Design

Volume 23, Issue 11, pp. 1633-1638

DOI: 10.2174/1381612823666161116125218

Field-Weighted Citation Impact: 5.61