Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis

2016420 citationsReviewgold Open Access

Authors

Luca A. Lotta · University of Cambridge

Robert A. Scott · University of Cambridge

Stephen J. Sharp · University of Cambridge

Stephen Burgess · University of Cambridge

Jian’an Luan · University of Cambridge

Therese Tillin · University College London

Amand F. Schmidt ·

Abstract

Evidence from this large-scale human genetic and metabolomic study is consistent with a causal role of BCAA metabolism in the aetiology of type 2 diabetes.

Topics & Keywords

Metabolomics and Mass Spectrometry Studies Genetic Associations and Epidemiology Liver Disease Diagnosis and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS Medicine

Volume 13, Issue 11, pp. e1002179-e1002179

DOI: 10.1371/journal.pmed.1002179

Field-Weighted Citation Impact: 18.45