Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

20161,283 citationsJournal Articlebronze Open Access

Authors

Marco Demaria · University Medical Center Groningen

Monique N. O’Leary · Buck Institute for Research on Aging

Jianhui Chang · University of Arkansas for Medical Sciences

Lijian Shao · University of Arkansas for Medical Sciences

Su Liu · Buck Institute for Research on Aging

Fatouma Alimirah · Buck Institute for Research on Aging

Kristin L Koenig

Abstract

Many genotoxic chemotherapies have debilitating side effects and also induce cellular senescence in normal tissues. The senescent cells remain chronically present where they can promote local and systemic inflammation that causes or exacerbates many side effects of the chemotherapy. Cancer Discov; 7(2); 165-76. ©2016 AACR.This article is highlighted in the In This Issue feature, p. 115.

Topics & Keywords

Telomeres, Telomerase, and Senescence Immunotherapy and Immune Responses Immune cells in cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancer Discovery

Volume 7, Issue 2, pp. 165-176

DOI: 10.1158/2159-8290.cd-16-0241

Field-Weighted Citation Impact: 42.51