Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs Diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

20025,673 citationsJournal Article

Authors

The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group

Abstract

Thiazide-type diuretics are superior in preventing 1 or more major forms of CVD and are less expensive. They should be preferred for first-step antihypertensive therapy.

Topics & Keywords

Blood Pressure and Hypertension Studies Hormonal Regulation and Hypertension Renin-Angiotensin System Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA

Volume 288, Issue 23, pp. 2981-2997

DOI: 10.1001/jama.288.23.2981

Field-Weighted Citation Impact: 244.50