Self-neutralizing oligonucleotides with enhanced cellular uptake

201710 citationsJournal Articlegreen Open Access

Authors

Ivan B. Yanachkov · Glsynthesis

Boris Zavizion · Zata Pharmaceuticals (United States)

Valeri Metelev · Lomonosov Moscow State University

Laura J. Stevens · Zata Pharmaceuticals (United States)

Yekaterina Tabatadze · Zata Pharmaceuticals (United States)

Milka Yanachkova · Glsynthesis

George E. Wright

Abstract

There is tremendous potential for oligonucleotide (ON) therapeutics, but low cellular penetration due to their polyanionic nature is a major obstacle.

Topics & Keywords

DNA and Nucleic Acid Chemistry Advanced biosensing and bioanalysis techniques RNA Interference and Gene Delivery

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: Organic & Biomolecular Chemistry

Volume 15, Issue 6, pp. 1363-1380

DOI: 10.1039/c6ob02576e

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