Mutational Profile of Metastatic Breast Cancers: A Retrospective Analysis

2016400 citationsJournal Articlegold Open Access

Authors

Céline Lefèbvre · Inserm

Thomas Bachelot · Inserm

Thomas Filleron · Institut Claudius Regaud

Marion Pedrero · Inserm

Mario Campone · Institut de Cancérologie de l'Ouest

Jean‐Charles Soria · Université Paris-Sud

Christophe Massard ·

Abstract

This work reports the results of the analysis of the first large-scale study on mutation profiles of mBC. This study revealed genomic alterations and mutational signatures involved in the resistance to therapies, including actionable mutations.

Topics & Keywords

Cancer Genomics and Diagnostics Cancer-related Molecular Pathways BRCA gene mutations in cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS Medicine

Volume 13, Issue 12, pp. e1002201-e1002201

DOI: 10.1371/journal.pmed.1002201

Field-Weighted Citation Impact: 14.94