Deletion of Nlrp3 protects from inflammation-induced skeletal muscle atrophy

201792 citationsJournal Articlegold Open Access

Authors

Nora Huang · Max Delbrück Center

Melanie Kny · Max Delbrück Center

Fabian Riediger · Charité - Universitätsmedizin Berlin

Katharina Büsch · Max Delbrück Center

Sibylle Schmidt · Charité - Universitätsmedizin Berlin

Friedrich C. Luft · Max Delbrück Center

Hortense Slevogt

Abstract

IL-1β directly acts on myocytes to cause atrophy in sepsis. Inhibition of IL-1β activation by targeting Nlrp3 could be useful to prevent inflammation-induced muscle failure in critically ill patients.

Topics & Keywords

Exercise and Physiological Responses Fibromyalgia and Chronic Fatigue Syndrome Research Long-Term Effects of COVID-19

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Intensive Care Medicine Experimental

Volume 5, Issue 1, pp. 3-3

DOI: 10.1186/s40635-016-0115-0

Field-Weighted Citation Impact: 4.24