The release and trans-synaptic transmission of Tau via exosomes

2017673 citationsJournal Articlegold Open Access

Authors

Yipeng Wang · German Center for Neurodegenerative Diseases

Varun Balaji · German Center for Neurodegenerative Diseases

Senthilvelrajan Kaniyappan · German Center for Neurodegenerative Diseases

Lars Krüger · German Center for Neurodegenerative Diseases

Stephan Irsen · Center of Advanced European Studies and Research

Katharina Tepper · German Center for Neurodegenerative Diseases

RamReddy Chandupatla

Abstract

Our study demonstrates that exosomes contribute to trans-synaptic Tau transmission, and thus offer new approches to control the spreading of pathology in AD and other tauopathies.

Topics & Keywords

Extracellular vesicles in disease Neuroinflammation and Neurodegeneration Mechanisms Alzheimer's disease research and treatments

UN Sustainable Development Goals

Life in Land

Publication Details

Published in: Molecular Neurodegeneration

Volume 12, Issue 1, pp. 5-5

DOI: 10.1186/s13024-016-0143-y

Field-Weighted Citation Impact: 25.52