NEK2 Promotes Aerobic Glycolysis in Multiple Myeloma Through Regulating Splicing of Pyruvate Kinase

2017147 citationsJournal Articlegold Open Access

Authors

Zhimin Gu · University of Iowa

Jiliang Xia · Southern Medical University

Hongwei Xu · University of Iowa

Ivana Frech · University of Iowa

Guido Tricot · University of Iowa

Fenghuang Zhan · University of Iowa

Abstract

Our studies demonstrate that NEK2 promotes aerobic glycolysis through regulating splicing of PKM and increasing the PKM2/PKM1 ratio in myeloma cells which contributes to its oncogenic activity.

Topics & Keywords

Cancer, Hypoxia, and Metabolism Acute Myeloid Leukemia Research Protein Degradation and Inhibitors

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Hematology & Oncology

Volume 10, Issue 1, pp. 17-17

DOI: 10.1186/s13045-017-0392-4

Field-Weighted Citation Impact: 3.83