Four-Dimensional Microvascular Analysis Reveals That Regenerative Angiogenesis in Ischemic Muscle Produces a Flawed Microcirculation

201766 citationsJournal Articlebronze Open Access

Authors

John‐Michael Arpino · Western University

Zengxuan Nong · Western University

Fuyan Li · Western University

Hao Yin · Western University

Nour Ghonaim · Western University

Stephanie Milkovich · Western University

Brittany Balint · Western University

Abstract

Despite robust neovascularization, the microcirculation formed by regenerative angiogenesis in skeletal muscle is profoundly flawed in both structure and function, with no evidence for normalizing over time. This network-level dysfunction must be recognized and overcome to advance regenerative approaches for ischemic disease.

Topics & Keywords

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Publication Details

Published in: Circulation Research

Volume 120, Issue 9, pp. 1453-1465

DOI: 10.1161/circresaha.116.310535

Field-Weighted Citation Impact: 6.60

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Four-Dimensional Microvascular Analysis Reveals That Regenerative Angiogenesis in Ischemic Muscle Produces a Flawed Microcirculation

Authors

Abstract

Topics & Keywords

Publication Details