A Randomized Phase III Clinical Trial of Plecanatide, a Uroguanylin Analog, in Patients With Chronic Idiopathic Constipation

2017138 citationsJournal Article

Authors

Philip B. Miner · Oklahoma Foundation for Digestive Research

William Koltun · Center for Clinical Research (United States)

Gregory Wiener · Precision Research Institute

Marianela De La Portilla · Genomatica (United States)

Blas Prieto · Advanced Medical Research Institute

Kunwar Shailubhai · Synergy Pharmaceuticals (United States)

Mary Beth Layton

Abstract

Plecanatide significantly improved constipation and its related symptoms with a low rate of adverse events. These results suggest that plecanatide will be a useful treatment option in the management of CIC. ClinicalTrials.gov: NCT01982240.

Topics & Keywords

Gastrointestinal motility and disorders Congenital gastrointestinal and neural anomalies Infant Health and Development

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The American Journal of Gastroenterology

Volume 112, Issue 4, pp. 613-621

DOI: 10.1038/ajg.2016.611

Field-Weighted Citation Impact: 14.57