Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease

2017263 citationsJournal Articlehybrid Open Access

Authors

Tom R. Webb · University of Leicester

Jeanette Erdmann · University of Lübeck

Kathleen Stirrups · William Harvey Research Institute

Nathan O. Stitziel · James S. McDonnell Foundation

Nicholas G. D. Masca · University of Leicester

Henning Jansen · Technical University of Munich

Stavroula Kanoni

Abstract

We identified 6 loci associated with CAD at genome-wide significance. Several CAD loci show substantial pleiotropy, which may help us understand the mechanisms by which these loci affect CAD risk.

Topics & Keywords

Cardiovascular Health and Disease Prevention Cerebrovascular and Carotid Artery Diseases Cardiac Imaging and Diagnostics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of the American College of Cardiology

Volume 69, Issue 7, pp. 823-836

DOI: 10.1016/j.jacc.2016.11.056

Field-Weighted Citation Impact: 24.29