IL-6 induced lncRNA MALAT1 enhances TNF-α expression in LPS-induced septic cardiomyocytes via activation of SAA3.

201789 citationsJournal Article

Authors

Y-T Zhuang · Yidu Central Hospital of Weifang

D-Y Xu

Abstract

IL-6 induced MALAT1 upregulation in cardiomyocytes in response to LPS treatment. MALAT1 can enhance TNF-α expression at least partly via SAA3 in LPS-treated cardiomyocytes. MALAT1 upregulation is a mechanism of cardiomyocyte death in response to the LPS stimulation.

Topics & Keywords

Peroxisome Proliferator-Activated Receptors Helicobacter pylori-related gastroenterology studies Pharmacological Effects of Natural Compounds

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PubMed

Volume 21, Issue 2, pp. 302-309

Field-Weighted Citation Impact: 5.10