Effects of CTGF Blockade on Attenuation and Reversal of Radiation-Induced Pulmonary Fibrosis

2016151 citationsJournal Articlebronze Open Access

Authors

Sebastian Bickelhaupt · University Hospital Heidelberg

Christian Erbel · FibroGen (United States)

Carmen Timke · University Hospital Heidelberg

Ute Wirkner · German Cancer Research Center

Monika Dadrich · Heidelberg University

Paul Flechsig · University Hospital Heidelberg

Alexandra Tietz

Abstract

These results indicate that blocking CTGF attenuates radiation-induced pulmonary remodeling and can reverse the process after initiation. CTGF has a central role in radiation-induced fibrogenesis, and FG-3019 may benefit patients with radiation-induced pulmonary fibrosis or patients with other forms or origin of chronic fibrotic diseases.

Topics & Keywords

Connective Tissue Growth Factor Research Fibroblast Growth Factor Research Systemic Sclerosis and Related Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 109, Issue 8

DOI: 10.1093/jnci/djw339

Field-Weighted Citation Impact: 8.47