Comprehensive pharmacogenetic profiling of the epidermal growth factor receptor pathway for biomarkers of response to, and toxicity from, cetuximab

20174 citationsJournal Article

Authors

Ayman Madi · Cardiff University

David J. Fisher · MRC Clinical Trials Unit at UCL

Tim Maughan · Cardiff University

James Colley · Cardiff University

Angela Meade · MRC Clinical Trials Unit at UCL

Sabine Tejpar · KU Leuven

Ben Van den Bosch ·

Abstract

Our study highlights the need to validate potential pharmacogenetic biomarkers. We did not find strong evidence for common germline biomarkers of cetuximab response and toxicity.

Topics & Keywords

Colorectal Cancer Treatments and Studies Genetic factors in colorectal cancer Lung Cancer Treatments and Mutations

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Medical Genetics

Volume 54, Issue 8, pp. 567-571

DOI: 10.1136/jmedgenet-2016-104317

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