Mismatch Repair Deficiency, Microsatellite Instability, and Survival

2017514 citationsJournal Articlebronze Open Access

Authors

Elizabeth Smyth · Royal Marsden Hospital

Andrew Wotherspoon · Royal Marsden Hospital

Clare Peckitt · Royal Marsden Hospital

David González · Institute of Cancer Research

Sanna Hulkki-Wilson · Institute of Cancer Research

Zakaria Eltahir · Royal Marsden Hospital

Matteo Fassan ·

Abstract

In the MAGIC trial, MMRD and high MSI were associated with a positive prognostic effect in patients treated with surgery alone and a differentially negative prognostic effect in patients treated with chemotherapy. If independently validated, MSI or MMRD determined by preoperative biopsies could be used to select patients for perioperative chemotherapy.

Topics & Keywords

Genetic factors in colorectal cancer Gastric Cancer Management and Outcomes Colorectal Cancer Treatments and Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA Oncology

Volume 3, Issue 9, pp. 1197-1197

DOI: 10.1001/jamaoncol.2016.6762

Field-Weighted Citation Impact: 32.97