Search for<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msup><mml:mrow><mml:mi mathvariant="italic">D</mml:mi></mml:mrow><mml:mrow><mml:mn>0</mml:mn></mml:mrow></mml:msup></mml:mrow><mml:mi>−</mml:mi><mml:mrow><mml:msup><mml:mover><mml:mrow><mml:mi mathvariant="italic">D</mml:mi></mml:mrow><mml:mrow><mml:mi>¯</mml:mi></mml:mrow></mml:mover><mml:mrow><mml:mi/><mml:mn>0</mml:mn></mml:mrow></mml:msup></mml:mrow></mml:math>Mixing

We have studied the "wrong-sign" process D0-->K+pi(-) to search for D0-&Dmacr;( 0) mixing. The data come from 9.0 fb(-1) of e(+)e(-) collisions at sqrt[s] approximately 10 GeV recorded with the CLEO II. V detector. We measure the relative rate of the wrong-sign process D0-->K+pi(-) to the Cabibbo-favored process &Dmacr;( 0)-->K+pi(-) to be R = (0.332(+0.063)(-0.065)+/-0.040)%. We study D0-->K+pi(-) as a function of decay time to distinguish direct doubly Cabibbo-suppressed decay from D0-&Dmacr;( 0) mixing. The amplitudes that describe D0-&Dmacr;( 0) mixing, x(') and y('), are consistent with zero. At the 95% C.L. and without assumptions concerning charge-parity ( CP) violating parameters, we find (1/2)x('2)<0.041% and -5.8%<y(')<1.0%.