A genetic female mouse model with congenital genitourinary anomalies and adult stages of urinary incontinence

20173 citationsJournal Article

Authors

Pedram Akbari · Hospital for Sick Children

Ali Fathollahi · New York Medical College

Rong Mo · Hospital for Sick Children

Michael Kavran · Case Western Reserve University

Nicole C. Episalla · Georgetown University

Chi‐Chung Hui · Amgen (Canada)

Walid A. Farhat ·

Abstract

Gli2+/- ; Gli3Δ699/+ adult female mice display persistent urinary incontinence due to the malformation of the bladder outlet and urethra. This presents a consistent and reliable genetic mouse model for female urinary incontinence and alludes to the key role of genetic factors involved in the condition.

Topics & Keywords

Urological Disorders and Treatments Congenital gastrointestinal and neural anomalies Tissue Engineering and Regenerative Medicine

Publication Details

Published in: Neurourology and Urodynamics

Volume 36, Issue 8, pp. 1981-1987

DOI: 10.1002/nau.23230

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A genetic female mouse model with congenital genitourinary anomalies and adult stages of urinary incontinence

Authors

Abstract

Topics & Keywords

Publication Details