Transgenic mice overexpressing desmocollin-2 (DSC2) develop cardiomyopathy associated with myocardial inflammation and fibrotic remodeling

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Authors

Andreas Brodehl · Libin Cardiovascular Institute of Alberta

Darrell D. Belke · Libin Cardiovascular Institute of Alberta

Lauren Garnett · University of Calgary

Kristina Martens · University of Calgary

Nelly Abdelfatah · Libin Cardiovascular Institute of Alberta

M. Rodriguez · University of Calgary

Catherine Diao

Abstract

Cardiac specific overexpression of desmocollin-2 induces necrosis, acute inflammation and patchy cardiac fibrotic remodeling leading to fulminant biventricular cardiomyopathy.

Topics & Keywords

Cardiovascular Effects of Exercise Cardiomyopathy and Myosin Studies Viral Infections and Immunology Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 12, Issue 3, pp. e0174019-e0174019

DOI: 10.1371/journal.pone.0174019

Field-Weighted Citation Impact: 4.10