Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score

2017403 citationsJournal Articlegold Open Access

Authors

Rahul S. Desikan · University of California, San Francisco

Chun Chieh Fan · University of California San Diego

Yunpeng Wang · Oslo University Hospital

Andrew J. Schork · University of California San Diego

Howard Cabral · Boston University

L. Adrienne Cupples · Boston University

Wesley K. Thompson

Abstract

We have developed a PHS for quantifying individual differences in age-specific genetic risk for AD. Within the cohorts studied here, polygenic architecture plays an important role in modifying AD risk beyond APOE. With thorough validation, quantification of inherited genetic variation may prove useful for stratifying AD risk and as an enrichment strategy in therapeutic trials.

Topics & Keywords

Health, Environment, Cognitive Aging Genetic Associations and Epidemiology Genetics, Aging, and Longevity in Model Organisms

Publication Details

Published in: PLoS Medicine

Volume 14, Issue 3, pp. e1002258-e1002258

DOI: 10.1371/journal.pmed.1002258

Field-Weighted Citation Impact: 26.74

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Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score

Authors

Abstract

Topics & Keywords

Publication Details