Migration of mitochondrial DNA in the nuclear genome of colorectal adenocarcinoma

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Authors

Vinodh Srinivasainagendra · University of Alabama at Birmingham

Michael J. Sandel · University of Alabama at Birmingham

Bhupendra Singh · University of Alabama at Birmingham

Aishwarya Sundaresan · University of Alabama at Birmingham

Ved P. Mooga · University of Alabama at Birmingham

Prachi Bajpai · University of Alabama at Birmingham

Hemant K. Tiwari

Abstract

Our study demonstrates increased somatic transfer of mtDNA in colorectal tumors. Our study also reveals sex-based differences in frequency of NUMT occurrence and that NUMT in blood reflects NUMT in tumors, suggesting NUMT may be used as a biomarker for tumorigenesis. We identify YME1L1 as the first NUMT suppressor gene in human and demonstrate that inactivation of YME1L1 induces migration of mtDNA to the nuclear genome. Our study reveals that numtogenesis plays an important role in the development of cancer.

Topics & Keywords

Genomics and Phylogenetic Studies Cancer Genomics and Diagnostics Mitochondrial Function and Pathology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Genome Medicine

Volume 9, Issue 1, pp. 31-31

DOI: 10.1186/s13073-017-0420-6

Field-Weighted Citation Impact: 3.13